TABLE 2.
Kidney organic osmolyte, glucose, and glycine content in Aldor1+/+ and Aldor1−/− mice
| Substance | Concn (nM/mg of wet wt)a
|
|||
|---|---|---|---|---|
|
Aldor1+/+
|
Aldor1−/−
|
|||
| Medulla | Cortex | Medulla | Cortex | |
| myo-Inositol | 9.54 ± 0.46 | 3.99 ± 0.16 | 9.20 ± 0.30 | 4.53 ± 0.31 |
| Taurine | 12.33 ± 0.25 | 13.69 ± 0.59 | 12.98 ± 0.30 | 13.55 ± 0.53 |
| GPC | 6.48 ± 0.40 | 1.42 ± 0.20 | 5.88 ± 0.35 | 1.69 ± 0.23 |
| Sorbitol | 1.42 ± 0.15 | 0.087 ± 0.011 | <0.01* | <0.01* |
| Betaine | 7.84 ± 0.76 | 9.68 ± 0.55 | 8.40 ± 0.97 | 9.70 ± 0.50 |
| Glucose | 6.92 ± 0.97 | 8.12 ± 0.67 | 6.80 ± 0.73 | 7.41 ± 0.56 |
| Glycine | 5.43 ± 0.38 | 6.53 ± 0.45 | 5.59 ± 0.22 | 6.29 ± 0.20 |
a
Data are means ± standard errors of the means (n = 10). GPC, glycerophosphorylcholine. No significant difference between the two genotypes in osmolyte levels was observed except for that of sorbitol (*, P < 0.0001). Statistical significance was determined by the unpaired Student t test.