Table 3.

The pharmacokinetics properties of the selected compounds

	Caryophyllene oxide	Cymene	Eugenol	Ocimene	Terpinene	Thymol
Pharmacokinetics
GI absorption	High	Low	High	Low	Low	High
BBB permeant	Yes	Yes	Yes	Yes	Yes	Yes
P-gp substrate	No	No	No	No	No	No
CYP1A2 inhibitor	No	No	Yes	No	No	Yes
CYP2C19 inhibitor	Yes	No	No	No	No	No
CYP2C9 inhibitor	Yes	No	No	No	No	No
CYP2D6 inhibitor	No	Yes	No	No	No	No
CYP3A4 inhibitor	No	No	No	No	No	No
Log Kp (cm/s) *	−5.12	−4.21	−5.69	−4.11	−3.94	−4.87
Drug-likeness
Lipinski	Yes	Yes	Yes	Yes	Yes	Yes
Ghose	Yes	No	Yes	No	No	No
Veber	Yes	Yes	Yes	Yes	Yes	Yes
Egan	Yes	Yes	Yes	Yes	Yes	Yes
Muegge	No	No	No	No	No	No
Bioavailability score	0.55	0.55	0.55	0.55	0.55	0.55

^*Skin permeation.