Fig. 1.

Flow chart of experimental protocol. First, we simulated $g_1(\tau )$ at 1 and 2.5 cm for a wide range of physiologically relevant layer optical properties and thicknesses using the three-layer solution to the correlation diffusion equation. Next, simulated data were simultaneously fit for SBFi and CBFi using the three-layer model with assumed optical properties/thicknesses. Finally, we assessed the accuracy of both CBFi and relative changes of CBFi by comparing the estimated and true CBFi and rCBFi.