Table 2:
Metabolite levels in patients with Late-Life Depression (LLD) and Healthy Elderly Control (HC) subjects
| Metabolite [/tCr] | Anterior Cingulate | t | df | p | Effect Size1 | |
|---|---|---|---|---|---|---|
| HC Mean (SD) | LLD Mean (SD) | |||||
| GABA | 0.353 (0.080) | 0.334 (0.087) | 0.463 | 16 | 0.649 | 0.238 |
| Glu | 1.422 (0.163) | 1.405 (0.154) | 0.237 | 16 | 0.816 | 0.104 |
| GSH | 0.225 (0.049) | 0.226 (0.043) | −0.026 | 16 | 0.980 | −0.020 |
| NAA | 1.465 (0.128) | 1.411 (0.218) | 0.639 | 16 | 0.532 | 0.422 |
| NAAG | 0.166 (0.052) | 0.150 (0.097) | 0.423 | 16 | 0.678 | 0.308 |
| mI | 0.703 (0.142) | 0.785 (0.126) | −1.230 | 16 | 0.212 | −0.577 |
| Metabolite [/tCr] | Posterior Cingulate | t | df | p | Effect Size1 | |
|---|---|---|---|---|---|---|
| HC Mean (SD) | LLD Mean (SD) | |||||
| GABA | 0.337 (0.081) | 0.338 (0.061) | −0.023 | 16 | 0.982 | −0.012 |
| Glu | 1.323 (0.090) | 1.290 (0.140) | 0.585 | 16 | 0.568 | 0.366 |
| GSH | 0.217 (0.052) | 0.220 (0.045) | −0.102 | 16 | 0.920 | −0.058 |
| NAA | 1.510 (0.159) | 1.370 (0.102) | 2.209 | 16 | 0.042 | 0.881 |
| NAAG | 0.225 (0.098) | 0.209 (0.091) | 0.351 | 16 | 0.730 | 0.163 |
| mI | 0.670 (0.043) | 0.733 (0.088) | −1.024 | 16 | 0.321 | −1.465 |
Total creatine (tCr), γ-aminobutyric acid (GABA), glutamate (Glu), glutathione (GSH), N-acetylaspartate (NAA), N-acetylaspartylglutamate (NAAG) and myo-inositol (mI)
1
Effect size was calculated as the ratio of the between-group difference to the SD of the healthy older adult comparison group.
Statistically significant effects are indicated in boldface.