Table 3:
Metabolite levels in patients with Late-Life Depression at baseline and during Citalopram treatment
| Metabolite [/tCr] | Anterior Cingulate | t | df | p | Effect Size1 | |
|---|---|---|---|---|---|---|
| Time 1 Mean (SD) | Time 2 Mean (SD) | |||||
| GABA | 0.334 (0.087) | 0.319 (0.079) | 0.501 | 8 | 0.630 | 0.200 |
| Glu | 1.405 (0.154) | 1.318 (0.148) | 1.358 | 8 | 0.212 | 0.455 |
| GSH | 0.226 (0.043) | 0.224 (0.036) | 0.162 | 8 | 0.875 | 0.051 |
| NAA | 1.411 (0.218) | 1.369 (0.112) | 0.731 | 8 | 0.485 | 0.243 |
| NAAG | 0.150 (0.097) | 0.118 (0.097) | 0.725 | 8 | 0.489 | 0.244 |
| mI | 0.785 (0.126) | 0.702 (0.065) | 2.214 | 8 | 0.058 | 0.735 |
| Metabolite [/tCr] | Posterior Cingulate | t | df | p | Effect Size1 | |
|---|---|---|---|---|---|---|
| Time 1 Mean (SD) | Time 2 Mean (SD) | |||||
| GABA | 0.338 (0.061) | 0.337 (0.062) | 0.035 | 8 | 0.973 | 0.013 |
| Glu | 1.290 (0.140) | 1.244 (0.105) | 1.399 | 8 | 0.199 | 0.470 |
| GSH | 0.220 (0.047) | 0.221 (0.038) | −0.081 | 8 | 0.937 | −0.017 |
| NAA | 1.370 (0.102) | 1.388 (0.109) | −0.501 | 8 | 0.623 | 0.168 |
| NAAG | 0.209 (0.091) | 0.252 (0.039) | −1.072 | 8 | 0.315 | −0.361 |
| mI | 0.733 (0.088) | 0.703 (0.099) | 1.300 | 8 | 0.230 | 0.429 |
Total creatine (tCr), γ-aminobutyric acid (GABA), glutamate (Glu), glutathione (GSH), N-acetylaspartate (NAA), N-acetylaspartylglutamate (NAAG) and myo-inositol (mI)
1
Effect size was calculated as the ratio of the between-time-points difference to the SD of the between-time-points difference.