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. 2021 Nov 22;3:60. doi: 10.1186/s42466-021-00158-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — SARS-CoV-2 specific ELISpot and IgG responses in patients with multiple sclerosis (MS) and matched healthy controls (HC). a ELISpot responses to spike (S), b to membrane (M) and nucleocapsid (NC) and c IgG antibody responses against S1. Horizontal bold lines indicate median values, dashed lines the cutoff for positive responses (3 spots increment or antibody ratio of 1.1). S1: peptide mix of the SARS-CoV-2 spike (S) 1; S1/S2: peptide mix of the spike (S) 1 and S2; S Sino: S1 protein; M: peptide mix of the membrane; NC: peptide mix of the nucleocapsid. ***p < 0.0001 (Mann–Whitney test)