Table 5.
Comparison of the clinical presentations of patients in the ENG and ACVRL1 genetic variant groups
| Clinical characteristics | ENG (n=26) | ACVRL1 (n=16) | P-value |
|---|---|---|---|
| Mean age (yr) | 55.3 | 53.4 | - |
| Curaçao criteriaa) | - | ||
| Definite | 17 (65) | 7 (44) | |
| Probable | 9 (35) | 8 (50) | |
| Unlikely | 0 | 1 (6) | |
| Clinical presentation | |||
| Epistaxis | 24 (92) | 14 (88) | 0.628 |
| Telangiectasia | 12 (46) | 9 (56) | 0.751 |
| Family history | 25 (96) | 12 (75) | 0.061 |
| AVM | 18 (42) | 9 (56) | 0.511 |
| Pulmonary | 12 (46) | 0 | <0.001 |
| Cerebral | 3 (12) | 4 (25) | 0.397 |
| Hepatic | 1 (4) | 3 (19) | 0.146 |
| Gastrointestinal | 2 (8) | 2 (13) | 0.628 |
Values are presented as number (%).
AVM, arteriovenous malformation.
a)
Classification according to the Curaçao criteria: definite, three or more criteria; probable, two criteria; unlikely; less than two criteria.