Fig. 1.

SARS-CoV-2 variants of concern exhibit four patterns of mutations in the spike glycoprotein. NTD, N-terminal domain; RBD, receptor binding domain; FP, fusion peptide; HR1, heptad repeat 1; HR2, heptad repeat 2; TM, transmembrane anchor; IC, intracellular tail. Mutations that distinguish variants of concern are colored based on each pattern: red, mutations in the NTD likely to evade binding of neutralizing antibodies, green, RBD mutations likely to evade binding of neutralizing antibodies, yellow, fusion cleavage site mutations, magenta, interchain contact mutations. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)