Fig. 4.

Model of interactions between SARS-CoV-2 spike protein variants and host receptors. A. Side view cartoon of potential spike protein/host receptor interactions showing the structure of the trimeric SARS-CoV-2 spike protomer (PDB 7CWN), with spheres indicating mutations that distinguish variants of concern: red, NTD, green, RBD, yellow, furin cleavage site, magenta, interchain contact mutations. ACE2 is shown in blue, as modeled based on the interaction of ACE2 and the RBD in PDB 6M17. CEA is shown in orange, as modeled based on the interaction of Mouse Hepatitis Virus NTD complexed to murine CEA (PDB 3R4D). B. Top view of interactions between the trimeric spike protein protomer (gray) with ACE2 (blue) and CEA (orange).