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Synthesis of target compounds 10 and 11. Reagents and conditions: (a) S-(+)-mandelic acid, 2-propanol, recrystallization, 52%; (b) R-(−)-mandelic acid, 2-propanol, crystallization, 56%; (c) NaOH, tert-butyl methyl ether, 2 h, 63–83%; (d) 4,7-dichloroquinoline, TEA, K2CO3, 135 °C, 24 h, 62–68%; (e) H2SO4, EtOH, reflux, 67–85%.
