Table 3.

Sensitivity Analyses (2019 US$)

	Direct costs			Total costs
	Cost per 500 mailers ($)	Average cost per person screened ($)	ICER†	Cost per 500 mailers ($)	Average cost per person screened ($)	ICER†
Base case*	5275.70	54.83	54.83	7014.45	72.90	72.90
Annual output
10,000 mailers	5275.70	54.83	54.83	7544.50	78.41	78.41
20,000 mailers	5275.70	54.83	54.83	6410.25	66.62	66.62
30,000 mailers	5275.70	54.83	54.83	6032.07	62.69	62.69
Unit costs—labor
20% increase	5493.89	57.10	57.10	7575.12	78.73	78.73
20% decrease	5057.50	52.56	52.56	6453.76	67.07	67.07
Unit costs—non-labor
20% increase	6112.64	63.53	63.53	7856.64	81.65	81.65
20% decrease	4438.75	46.13	46.13	6172.23	64.15	64.15
Unit costs—all
20% increase	6330.84	65.79	65.79	8417.32	87.48	87.48
20% decrease	4220.56	43.86	43.86	5611.55	58.32	58.32
Navigation to colonoscopy
30 min	5325.26	55.34	55.34	7064.00	73.41	73.41
45 min	5374.83	55.86	55.86	7113.57	73.93	73.93
Baseline screen rate‡
2.5%	5275.70	54.83	60.03	7014.45	72.90	80.80
5.0%	5275.70	54.83	67.05	7014.45	72.90	91.47

*Base case assumes 13,050 mailers annually, all unit costs (wages, supplies, postage, processing fee) as occurred in study, mean time per navigation call is 15 min, and usual care comprises no screening at no cost

^†ICER = incremental cost divided by incremental number of persons screened. In all scenarios except those that vary the baseline screen rate, the ICER is identical to the average cost per person screened

^‡Assumes usual care pays for processing fee ($20 per screen). For example, if the baseline screen rate is 5%, then the expected number of persons screened in usual care is 25 (500*.05) and the total cost of usual care is $500 (25*$20). In this scenario, ICER = ($7014.45 − $500)/(96.22 − 25) = $91.47