Table 2.
Placental histopathological findings of all COVID-19 placental tissues according to COVID-19 symptomatology and diagnosis of pneumonia.
| Variables | All COVID-19 cases (n = 106) | COVID-19 symptomatic (n = 46) | COVID-19 asymptomatic (n = 60) | P-value a | COVID-19 symptomatic with pneumonia (n = 12) | COVID-19 symptomatic without pneumonia (n = 34) | P-valueb |
|---|---|---|---|---|---|---|---|
| Placental weight (gr) | 513.84 ± 102.76 | 525.24 ± 108.59 | 504.86 ± 98.03 | 0.307 | 512.58 ± 117.28 | 530.12 ± 106.82 | 0.636 |
| Placental weight centile | 19.18 ± 19.05 | 21.48 ± 20.11 | 17.42 ± 18.16 | 0.279 | 19.50 ± 14.26 | 22.18 ± 21.95 | 0.697 |
| Thrombosis, n (%) | 0 | 0 | 0 | n.a. | 0 | 0 | n.a. |
| Accelerated maturation, n (%) | 6 (5.7) | 1 (2.2) | 5 (8.3) | 0.190 | 1 (8.3) | 0 (0) | 0.089 |
| Chronic Histiocytic Intervillositis, n (%) | 8 (7.5) | 3 (6.5) | 5 (8.3) | 0.726 | 2 (16.7) | 1 (2.9) | 0.098 |
| Infarct lesions, n (%) | 14 (13.2) | 5 (10.9) | 9 (15) | 0.534 | 2 (16.7) | 3 (8.8) | 0.453 |
| Inflammatory lesions, n (%) | 16 (15.1) | 7 (15.2) | 9 (15) | 0.975 | 3 (25) | 4 (11.8) | 0.272 |
| Delayed maturation, n (%) | 16 (15.1) | 6 (13.0) | 10 (16.7) | 0.784 | 0 (0) | 6 (17.6) | 0.119 |
| Intervillar thrombosis, n (%) | 18 (16.9) | 6 (13.0) | 12 (20) | 0.344 | 0 (0) | 6 (17.6) | 0.119 |
| Fibrotic villous, n (%) | 26 (24.5) | 13 (28.3) | 13 (21.7) | 0.434 | 1 (8.3) | 12 (35.3) | 0.075 |
| Villar hypoplasia, n (%) | 27 (25.5) | 11 (23.9) | 16 (26.7) | 0.747 | 3 (25) | 8 (23.5) | 0.918 |
| Chorangiosis, n (%) | 38 (35.8) | 19 (41.3) | 19 (31.7) | 0.305 | 5 (41.7) | 12 (41.2) | 0.976 |
| Excessive fibrin deposition, n (%) | 46 (43.4) | 20 (43.5) | 26 (43.3) | 0.988 | 6 (50) | 14 (41.2) | 0.596 |
| Neointimal hyperplasia, n (%) | 81 (76.4) | 38 (82.6) | 43 (71.7) | 0.188 | 7 (58.3) | 31 (91.2) | 0.010* |
| Villar Agglutination, n (%) | 82 (77.3) | 35 (76.1) | 47 (78.3) | 0.784 | 7 (58.3) | 28 (82.4) | 0.094 |
| Syncytial node increase, n (%) | 102 (96.2) | 44 (95.6) | 58 (96.7) | 0.786 | 11 (91.7) | 33 (97.1) | 0.431 |
a
Comparison between symptomatic and asymptomatic cases.
b
Comparison between symptomatic with and without pneumonia cases.
Continuous variables are expressed as mean ± standard deviation; categorical variables as number and percentages.
Placental weight centiles calculated according to Almog et al. (14). Histopathological findings were reported according to Benton et al. (18).
The value is in bold since it is the only statistically significant value.
The value indicated with * is the only statistically significant value.