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. 2021 Nov 8;9:748039. doi: 10.3389/fcell.2021.748039

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Copyright © 2021 Fu and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of the independent prognostic genes in vivo and in vitro. (A) HCC Model design. FVB mice were injected with normal saline or sgP53/c-Myc/SB plasmids, respectively. (B) Representative liver tissues of normal (left) and HCC mice (middle) and tumor numbers (right). (C–E) The mRNA expressions of GSDME, GPX4, and SCAF11 in the normal and HCC livers. (F–H) The mRNA expressions of GSDME, GPX4, and SCAF11 in the human normal liver cell HL-7701 and liver cancer cell SK-Hep1. *p < 0.05, **p < 0.01, ***p < 0.001.