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. 2021 Nov 8;8:752875. doi: 10.3389/fmed.2021.752875

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Copyright © 2021 Khanam and Kottilil.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Targeting stem cell therapy for the treatment of ACLF. Use of mesenchymal stem cells is under consideration and is being investigated in clinical trials for the treatment of ACLF. Mesenchymal stem cells possess different functions including the suppression of hyperactive inflammatory response, inhibition of hepatic stellate cell activation and collagen synthesis, reducing fibrosis and inducing liver regeneration. The diverse role of mesenchymal stem cells may benefit patients with ACLF and emerge as a potential therapeutic option for these patients. HSC: hepatic stellate cells. Some parts of this figure (Human structure) were prepared with the help of BioRender.