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. 2021 Jun 29;92(12):1289–1295. doi: 10.1136/jnnp-2020-325537

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Longitudinal trajectories of plasma p-Tau181 and plasma NfL concentrations in the different ATN groups (A) log₁₀ plasma p-Tau181 (B) log₁₀ plasma NFL. Rate of change over time (slope) obtained using a LMEM (C) plasma p-Tau181 (normalised) and (D) plasma NfL concentrations (normalised) comparing the ATN groups. A+/−, amyloid-β positive/negative; ATN, Aβ deposition, tau pathology and neurodegeneration; LMEM, linear mixed effects model; NfL, neurofilament light protein, picogram per millilitre; p-Tau181, tau phosphorylated at threonine 181; TN+/−, tau/neurodegeneration.