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. 2021 Jun 29;92(12):1289–1295. doi: 10.1136/jnnp-2020-325537

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Association of plasma biomarkers with flortaucipir uptake after approximately 5 years time. (A) Log₁₀ plasma p-Tau181 (B) plasma NfL rate of change (slope) (C) log₁₀ plasma NfL baseline in the whole study cohort and within the ATN groups. Left: linear regression between biomarker and SUVR PET uptake in a meta ROI*. Right: Vertex-wise Pearson correlations adjusted for age, sex and the time difference between plasma sampling and flortaucipir PET (tfce FWE corrected p<0.05). AV45, 18F-florbetapir amyloid-β PET. *Flortaucipir meta ROI: entorhinal, amygdala, parahippocampal, fusiform, inferior temporal and middle-temporal-ROIs. A+/−, Aβ positive/negative; ATN, Aβ deposition, tau pathology and neurodegeneration; FWE, family-wise error corrected; NfL, neurofilament light chain; p-Tau181, tau phosphorylated at threonine 181; ROI, region of interest; SUVR, standardised uptake value; tfce, threshold free cluster enhancement; TN+/−, Tau/Neurodegeneration.