Figure 4.

Association of plasma biomarkers with florbetapir uptake after approximately 5 years time. (A) Log₁₀ plasma p-Tau181 B) log₁₀ plasma NfL baseline. Left: linear regression between biomarker and SUVR PET uptake in a meta ROI*. Right: Vertex-wise Pearson correlations adjusted for age, sex and the time difference between plasma sampling and florbetapir PET (tfce FWE corrected p<0.05). *Florbetapir meta ROI: frontal, anterior/posterior cingulate, lateral parietal, lateral temporal regions. bL, baseline; FWE, family-wise error corrected; NFfL, neurofilament light protein; ROI, region of interest; SUVR, standardised uptake value; tfce, threshold free cluster enhancement;