Table 1.

Probabilistic sensitivity analysis results per hour of faster treatment

Hour difference	Costs in € median (IQR)	QALY gained median (IQR)	NMB in € median (IQR)
First – second hour	2633 (−10,957;18,613)	0.36 (0.09;0.61)	23 799 (−3004;49,133)
Second – third hour	−2219 (−6,651;2,240)	0.15 (0.07;0.23)	14 052 (6,809;21,714)
Third – fourth hour	−3228 (−7,274;1,026)	0.34 (0.28;0.40)	30 143 (23,732;36,679)
Fourth – fifth hour	4666 (440;9,078)	0.22 (0.16;0.29)	13 125 (6,353;19,682)
Fifth – sixth hour	−3860 (−10,108;2,261)	0.09 (−0.01;0.18)	10 560 (1,708;19,971)
Per hour faster treatment*	−969 (−3,897;1,972)	0.22 (0.17;0.27)	18 513 (13,574;23,376)
Per 10 min faster treatment*	−151 (−649; 329)	13.5 (10.5;16.4)†	3085 (2,262;3,896)
Per minute faster treatment*	−15 (−65;33)	1.3 (1.0;1.6)†	309 (226;389)
Population outcome per hour of earlier treatment‡	−865,387 (−5,848,900;4,459,552)	210.1 (124.0;294.8)	17 239 435 (8,776,181;25,712,803)
Population outcome per 10 min of earlier treatment‡	−144,231 (−974,817;743,258)	35.0 (20.7;49.1)	2 873 239 (1,462,696;4,285,467)
Population outcome per minute of earlier treatment§	−14,423 (−97,482;74,326)	3.5 (2.1;4.9)	287 324 (146,270;428,547)

*For each simulation the median value of the five differences between 6 hours was taken.

†The per minute QALY results are depicted as disability-free life days gained (DALY). This is the daily value of a QALY (DALY=QALY/365).

‡Outcome for the Dutch LVO stroke population if faster EVT is performed.