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. 2021 Nov 8;13:756249. doi: 10.3389/fnagi.2021.756249

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Copyright © 2021 Toh and Siow.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Example of how regions of interest (ROIs) were segmented. Transverse isotropic diffusion-weighted (A), apparent diffusion coefficient (B), and fractional anisotropy images show manually drawn ROIs for measurement of infarct volume, ADC, and FA values. Directionally encoded color map (D) illustrates ROIs of projection (blue area) and association (green area) fibers in bilateral periventricular regions. On the co-registered isotropic diffusion-weighted (E) and apparent diffusion coefficient (F) images, these ROIs do not include infarcted tissue.