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. 2021 Nov 8;15:759223. doi: 10.3389/fncel.2021.759223

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Copyright © 2021 Xu, Rai and Zuo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Forced transcription factor expression alone in lateral GER cells didn’t lead to any conversion. (B–E) Ectopic expression of Tub or Znf532 promotes the Atoh1 mediated conversion in lateral GER. (C) A representative negative control showing Six2 failed to promote the Atoh1 mediated conversion. (D,E) The explants shown were transfected with combinations of Atoh1 + Tub and Atoh1 + Znf532. (F) Statistical data showed that there are significant increases in the conversion rate with Atoh1 + Znf532 and Atoh1 + Tub compared with Atoh1 alone. Scale bar= 20 μm. **P < 0.01 by unpaired two-tailed Student’s t-test. Results are presented as the mean ± SEM.