Table 2.
Multivariate Cox regression model analysis of OS in different age groups.
| Characteristics | 18–45 |
46–55 |
56–65 |
>65 |
||||
|---|---|---|---|---|---|---|---|---|
| HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | |
| Year | ||||||||
| 2000–2009 | Reference | Reference | Reference | Reference | ||||
| 2010–2015 | 0.97(0.61–1.53) | 0.880 | 0.75(0.50–1.13) | 0.165 | 1.04(0.73–1.47) | 0.831 | 0.78(0.65–0.95) | 0.011 |
| Race | ||||||||
| White | Reference | Reference | Reference | Reference | ||||
| Black | 1.19(0.78–1.82) | 0.425 | 0.91(0.59–1.41) | 0.679 | 1.56(1.08–2.25) | 0.016 | 0.95(0.76–1.18) | 0.623 |
| Others | 1.34(0.72–2.49) | 0.353 | 0.89(0.49–1.61) | 0.692 | 0.66(0.35–1.27) | 0.215 | 0.89(0.65–1.22) | 0.476 |
| Marital status | ||||||||
| Married | Reference | Reference | Reference | Reference | ||||
| Not married | 1.81(1.24–2.64) | 0.002 | 1.41(1.01–1.96) | 0.045 | 1.04(0.77–1.41) | 0.779 | 1.74(1.47–2.06) | <0.001 |
| Laterality | ||||||||
| Left | Reference | Reference | Reference | Reference | ||||
| Right | 0.93(0.65–1.34) | 0.713 | 0.97(0.71–1.34) | 0.869 | 1.12(0.84–1.50) | 0.430 | 0.90(0.78–1.05) | 0.187 |
| Histology | ||||||||
| IDC | Reference | Reference | Reference | Reference | ||||
| ILC and others | 0.92(0.59–1.44) | 0.707 | 0.70(0.47–1.06) | 0.089 | 0.95(0.68–1.33) | 0.760 | 0.95(0.81–1.11) | 0.488 |
| Grade | ||||||||
| I and II | Reference | Reference | Reference | Reference | ||||
| III and others | 1.53(0.93–2.52) | 0.092 | 1.38(0.88–2.16) | 0.155 | 2.24(1.57–3.21) | <0.001 | 1.70(1.43–2.03) | <0.001 |
| Tumor size | ||||||||
| 5–6 cm | Reference | Reference | Reference | Reference | ||||
| 6–8 cm | 1.62(0.98–2.68) | 0.058 | 1.32(0.85–2.04) | 0.222 | 1.24(0.85–1.79) | 0.259 | 0.92(0.76–1.13) | 0.438 |
| >8 cm | 1.75(0.97–3.17) | 0.065 | 1.70(1.05–2.73) | 0.029 | 1.09(0.69–1.73) | 0.715 | 1.02(0.80–1.31) | 0.862 |
| Others/Unknown | 1.95(1.18–3.24) | 0.009 | 1.43(0.91–2.27) | 0.124 | 1.19(0.78–1.80) | 0.428 | 0.99(0.81–1.21) | 0.936 |
| HoR | ||||||||
| Negative | Reference | Reference | Reference | Reference | ||||
| Positive | 0.74(0.49–1.11) | 0.146 | 0.51(0.34–0.77) | 0.001 | 0.79(0.57–1.10) | 0.165 | 0.85(0.70–1.02) | 0.088 |
| Chemotherapy | ||||||||
| No/Unknown | Reference | Reference | Reference | Reference | ||||
| Yes | 1.07(0.62–1.84) | 0.803 | 0.86(0.57–1.31) | 0.486 | 0.75(0.54–1.04) | 0.086 | 0.53(0.43–0.65) | <0.001 |
| Radiation | ||||||||
| No | Reference | Reference | Reference | Reference | ||||
| Yes | 0.74(0.50–1.08) | 0.119 | 0.91(0.65–1.28) | 0.603 | 0.67(0.49–0.92) | 0.014 | 0.60(0.50–0.72) | <0.001 |
Abbreviations: HoR, hormone receptor; HR, hazard ratio; IDC, infiltrating duct carcinoma; ILC, infiltrating lobular carcinoma.