Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 8;9:779432. doi: 10.3389/fcell.2021.779432

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Dai, Ye, Zhong, Chen, Hong, Zhao, Su and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

GSDMD-NT was upregulated in the heart tissue of septic mice induced by LPS. (A) Representative echocardiography of mice from each group. (B, C) Myocardial function parameters, ejection fraction (EF) and fractional shortening (FS) of mice from each group were assessed by echocardiography (n = 6). (D–F) The levels of cardiac troponin I (cTnI), creatine kinase isoenzymes MB (CK-MB) and lactate dehydrogenase (LDH) in serum from each group (n = 6). (G) Representative HE images of heart tissue from each group (magnification × 400). (H) Expressions of GSDMD and GSDMD-NT protein in heart tissue were measured by Western blotting analysis. The results were normalized to the expression of GAPDH (n = 6). Data are expressed as the mean ± standard deviation (SD). **p < 0.01, ***p < 0.001. ns: nonsignificance.