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. 2021 Nov 8;9:779432. doi: 10.3389/fcell.2021.779432

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Copyright © 2021 Dai, Ye, Zhong, Chen, Hong, Zhao, Su and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gsdmd deficiency improved the survival rate and attenuated myocardial injury and dysfunction in septic mice induced by LPS. (A) Survival rate of the WT-LPS group and Gsdmd ^−/−-LPS group (n = 10). (B) Representative echocardiography of mice from each group. (C, D) Myocardial function parameters, EF and FS of mice from each group were measured by echocardiography (n = 8). (E–G) The levels of cTnI, CK-MB, and LDH in serum from each group (n = 8). (H) Representative HE images of heart tissue from each group (magnification × 400). (I) Representative TUNEL images of heart tissue from each group (magnification × 400) and quantitative data of positive cells from randomly selected five fields are shown on the right (n = 5). Data are expressed as the mean ± SD. *p < 0.05, ***p < 0.001.