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. 2021 Nov 8;9:779432. doi: 10.3389/fcell.2021.779432

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Copyright © 2021 Dai, Ye, Zhong, Chen, Hong, Zhao, Su and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GSDMD enrichment in mitochondria leads to mitochondrial dysfunction, ROS generation, and NLRP3 inflammasome activation. (A) Expressions of GSDMD-NT protein in mitochondria of heart tissue were measured by Western blotting analysis. The results were normalized to the expression of COX-IV (n = 6). (B) Expressions of GSDMD-NT protein in mitochondria of H9c2 cells were measured by Western blotting analysis. The results were normalized to the expression of COX-IV (n = 3). (C) Mitochondrial membrane potential was assessed by JC assays in each group. (D) ATP level in each group (n = 3). (E) ROS level in H9c2 cells. (F) MDA levels in heart tissue from each group. (G) SOD activity in heart tissue from each group. The data are expressed as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001.