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. 2021 Nov 8;11:686308. doi: 10.3389/fonc.2021.686308

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Copyright © 2021 Strippoli, Fanizzi, Quaresmini, Nardone, Armenio, Figliuolo, Filotico, Fucci, Mele, Traversa, De Luca, Montagna, Ruggieri, Ferraiuolo, Macina, Tommasi, Sciacovelli, De Risi, Albano, Massafra and Guida

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative cases of patients obtaining a major response to cemiplimab. (A) An 88-year-old female with a large locally advanced cutaneous squamous cell carcinoma (laCSCC) of the left nasal-infraorbital region achieving a complete response. Neither had she received prior radiotherapy nor anticancer systemic therapy. (B) An 89-year-old man with a large laCSCC tumor of the right parotid region obtaining a complete response after 6 cycles of cemiplimab and concurrent radiotherapy. (C, D) A 67-year-old man with metastatic cutaneous squamous cell carcinoma in immunosuppressive therapy due to a previous kidney transplantation. The patient achieved a near-complete response both at the right zygomatic area and the metastatic lung lesions.