Table 4.

Studies with Platelet-Rich Combination Therapy for Facial Rejuvenation

Author, Year	No. of Patients	Condition	Treatment	Outcomes	Methods of Assessment
Ibrahim 201813	35	Atrophic post acne scars	PRP with micro-needling	Significant improvement in acne scars and facial aging.	Goodman and Baron’s global acne scarring system
				PRP with micro-needling had significantly lesser erythema and edema compared to than micro-needling alone
Min 201815	25	Acne scars	PRP with fractional CO2 laser treatment	Significant improvement, Patient satisfaction scores were also significantly higher in PRP and CO2 laser treatment than CO2 treatment alone.	Investigator global assessment scale, Patient satisfaction scores
Abdel Aal 201816	30	Acne scars	PRP with fractional CO2 laser treatment	Combination of fractional CO2 laser resurfacing and intradermal PRP was superior to CO2 laser alone for acne scar treatment	Evaluation was carried out through operating physicians, two blinded physicians as well as through patient’s satisfaction.
El-Domyati 201811	24	Atrophic acne scars	PRP with micro-needling	Improvement of dermal structures, combination with trichloroacetic acid more effective than PRP	Photography and punch biopsies
Al Taweel 201821	40	Atrophic acne scars	PRP combined with carboxytherapy and PRP with CO2 laser treatment	PRP combined with CO2 laser treatment significantly improved acne scars compared with PRP combined with carboxytherapy treatment.	Photographs and patient satisfaction score
Tenna 201725	30	Atrophic acne scars	Fat grafts with PRP	Improved scars by increasing skin and subcutaneous tissue thickness	FACE-Q postoperative module was administered to analyze each patient’s satisfaction
Asif 201612	50	Atrophic scars	PRP with micro-needling	Significant improvement in atrophic acne scars. Patient satisfaction scores were also significantly different between PRP and micro-needling	Goodman’s qualitative and quantitative scales
Faghihi 201617	16	Atrophic acne scars:	PRP with fractional CO2 laser treatment	Clinical improvement of acne scars was higher on the platelet-rich plasma-fractional CO2 laser treated side but the difference was not statistically significant.	Patient satisfaction and the objective evaluation of serial photographs
Zhu 201322	22	Acne or acne scar	PRP with fractional CO2 laser treatment	Improvement of >50%, and 91% of the patients were satisfied with the treatment.	Comparing pre- and post-treatment photographs of the patients
Lee 201118	14	Acne scars	PRP with fractional CO2 laser treatment	Enhanced recovery of laser-damaged skin and synergistically improved the clinical appearance of acne scarring.	Dermatologists evaluated clinical improvement using a quartile grading scale
El-Domyati 201810	24	Facial wrinkles and other signs of photoaging	PRP with micro-needling	Significant clinical improvement after treatment	Photography and punch biopsies
Deshmukh 201839	40	Atrophic acne scars	PRP with subcutaneous incision-less surgery (subcision)	Significant improvement was observed in PRP plus subcision compared with subcision alone.	Goodman and Baron’s qualitative acne scar grading system
Kar 201720	30	Atrophic acne scars	PRP with fractional CO2 laser treatment	Significant improvement on both sides of the face.	Goodman and Barons quantitative global acne scar grading system
Willemsen 201826	32	Loss of skin elasticity and tissue volume	PRP with lipofilling	No improvement in the outcome about skin elasticity, graft volume maintenance, and patient satisfaction, however, the recovery time was significantly reduced due to addition of PRP	Changes in skin elasticity, volumetric changes of the nasolabial fold, recovery time, and patient satisfaction
Ali 201832	63	Facial aging	PRP with thread-lifting	Highly augmented results are observed when combined with PRP	Patient satisfaction
Ibrahim 20179	90	Atrophic post-acne scars, atrophic post-traumatic scars, post chickenpox scars	PRP with micro-needling	Significant improvement in the appearance of atrophic scars	Clinical evaluation scale score
Ulusal 201735	94	Facial aging	PRP with hyaluronic acid	Significant improvement was observed regarding the general appearance	5-grade wrinkle severity rating scale and by patient satisfaction scores.
Hui 201719	13	Facial aging	PRP with fractional CO2 laser treatment	Subjective scores of facial wrinkles, skin texture, and skin elasticity were higher	Satisfaction scores, dermatologists’ double-blind evaluation and the VISIA skin analysis system
Kamakura 201536	2005	Wrinkles and depression in the skin	PRP with growth factor	Level of patient satisfaction was 97.3% and the level of investigator satisfaction was 98.4%.	Global Aesthetic Improvement Scale, Wrinkle Severity Rating Scale
Willemsen 201427	82	Loss of tissue volume, significant ptosis, and the subsequent descent of tissues	PRP with fat grafting	Significant drop in the number of days needed to recover.	Questionnaire based evaluation
van Dongen 202159	28	Facial aging	PRP supplemented lipofilling with stromal vascular fraction	In comparison to PRP-supplemented lipofilling, PRP-supplemented lipofilling combined with stromal vascular fraction does not improve facial skin quality or patient satisfaction.	Changes in skin elasticity and transepidermal water loss, changes in skin-aging-related features, ie, superficial spots, wrinkles, skin texture, pores, vascularity, and pigmentation, as well as patient satisfaction (FACE-Q), recovery, and number of complications
Abdel-Maguid 202137	33	Atrophic acne scars.	PRP with fractional CO2 laser	Better and faster improvement, dermal collagen and procollagen type 1 was increased after PRP therapy	Clinical assessment and Skin biopsies
Sasaki 201930	10	Facial aging	PRP with fat grafting	Improvement in the average percent change in mean volume assessments at the fat/PRP sites from baseline values	3D Vectra Analysis, VISIA, and Cortex facial skin analyses
El-Taieb 201923	75	Atrophic acne scars	PRP with erbium laser	Improvement with combined treatment was better than that with erbium-YAG laser or platelet-rich plasma alone	Acne scar grading, photography, and subjective evaluation.
Rigotti 201628	13	Facial aging	PRP with fat grafting	Presence of more pronounced inflammatory infiltrates and a greater vascular reactivity, increasing in vascular permeability and a certain reactivity of the nervous component.	Clinical observation, optical and electron microscopy
Alam 201814	27	Facial aging	PRP with micro-needling	Improved the visual appearance in individuals with photoaged skin, fine and coarse texture improved significantly.	Photoaging scores, self-assessment scores of improvements on a 5-point scale

Abbreviations: CO_2, carbon-dioxide; PRP, platelet-rich plasma.