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. 2021 Nov 8;12:698849. doi: 10.3389/fimmu.2021.698849

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Copyright © 2021 Ferreira-Gomes, Wich, Böde, Hube, Jacobsen and Jungnickel

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased antibody production upon stimulation with Zymosan or HKCA hyphae is not dependent on dectin-1 or specific B cell receptor recognition. Splenic B cells from Dectin-1^-/- and Dectin-1^+/+ mice (A, B) and B1-8f^tg/tg and B1-8f^+/+ mice (C, D) were cultured unstimulated or stimulated with LPS+IL-4 or anti-CD40+IL-4 in the presence of Zymosan, HKCA yeast or HKCA hyphae. After 5 days of culture, the percentage of IgG1-positive cells within live B cells was measured by flow cytometry (A, C), and the concentration of secreted IgG1 was measured by ELISA (B, D). Data represent mean ± SEM of 3 mice, with triplicate measurements performed for each mouse. *p < 0.05, **p < 0.005.