Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 8;11:761346. doi: 10.3389/fonc.2021.761346

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Yao, Wang, Zhu, Jia, Xu, Tian, Hu, Wu and Wei

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

HMGB1 inhibitor (Glycyrrhizin) notably suppresses in vitro and in vivo tumor growth of KMD4D^low ESCC. (A-C) Detection of the half maximal inhibitory concentration (IC50) values of Glycyrrhizin in three ESCC cell lines (KYSE30, EC109 and KYSE150). (D-F) The cell growth ability of the ESCC cells (KYSE30, EC109 and KYSE150) were all remarkably impaired with Glycyrrhizin treatment in a dose‐dependent manner. (G) HMGB1 inhibition (Glycyrrhizin) effectively suppressed ESCC subcutaneous tumour growth in nude mice (n = 5). (H) The tumour volume was detected every other day, and tumour growth curves were generated. (I) The tumours were extracted and weighed after 35 days. *P < 0.05, **P < 0.01, ***P < 0.001.