Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 8;8:737652. doi: 10.3389/fcvm.2021.737652

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Zhang, Feng, Li, Chen, Ning, Ou and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The RIPK3-p-MLKL pathway regulated the mitochondrial homeostasis in the Cd-induced AS. (A) Immunofluorescence images of mitochondrial membrane protein, Tom20, in the bone marrow-derived macrophages (BMDMs) of the ApoE^−/− or ApoE^−/−/RIPK3^−/− mice treated with Cd. (B,C) Immunofluorescence images and fluorescence intensity of the mitochondrial superoxide (mROS) in the BMDMs. (D,E) Mitochondrial membrane potential stained with a fluorescent probe (JC-1). (F,G) The protein expression levels of Opa1, Drp1, LC3I, and LC3II in the mitochondria of the aortic arch in the ApoE^−/− or ApoE^−/−/RIPK3^−/− mice treated with Cd. COX-IV is the internal reference of the mitochondrial protein. (H) The ratio of LC3II and LC3I indicating the autophagy level (n = 5–7 per group). Data are shown as mean ± SD. ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001.