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. 2021 Nov 8;8:737652. doi: 10.3389/fcvm.2021.737652

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Copyright © 2021 Zhang, Feng, Li, Chen, Ning, Ou and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Improving mitochondrial homeostasis through RIPK3 inhibition restored the balance of the macrophage polarization in vitro. (A,B) The protein expression levels of RIPK3 and p-MLKL in RAW264.7 treated with Cd, NAC, and Mdivi-1. (C) Immunofluorescence images of the mitochondrial membrane protein, Tom20, in the RAW264.7 cells. (D,E) Immunofluorescence images and fluorescence intensity of LC3II in the RAW264.7 cells. (F,G) The protein expression levels of NLRP3, pro-IL-1β, pNF-KB, and TNF-α in the RAW264.7 treated with Cd, N-Acetyl-L-cysteine (NAC), and mitochondrial division inhibitor-1 (Mdivi-1). Data are shown as mean ± SD. ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001.