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. 2021 Nov 8;12:769242. doi: 10.3389/fimmu.2021.769242

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Copyright © 2021 Schäfer, Rasras, Ormenisan, Amslinger, Enzmann, Jägle and Pauly

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FHR-3 and FH interacted with OSEs and RETC-2 reduced this competitive binding. All three lipid peroxidation products (A) CEP, (D) MDA, and (G) MAA interacted concentration dependently with FHR-3 and FH. FH (black) showed a higher binding strength than FHR-3 (grey) to the OSE. Interaction of FHR-3 with (B) CEP, (E) MDA, or (H) MAA could not be reduced by additional incubation with FH, but RETC-2 significantly reduced the binding of FHR-3 to all three peroxidation products. Interaction of FH to (C) CEP, (F) MDA, and (I) MAA was significantly reduced by additional incubation with FHR-3, and anti-FHR-3 antibody RETC-2 was able to reverse this inhibitory effect completely (F, MDA), partially (C, CEP), or not at all (I, MAA). ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05 (one-way ANOVA with Dunnett’s multiple comparisons test, n = 3).