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. 2021 Nov 8;12:769242. doi: 10.3389/fimmu.2021.769242

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Copyright © 2021 Schäfer, Rasras, Ormenisan, Amslinger, Enzmann, Jägle and Pauly

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RETC-2-ximab slightly ameliorated the effect of FHR-3 on ARPE-19 cells. ARPE-19 cells were treated with either FHR-3 (black), FHR-3 and control-ximab (anti-BSA, dark grey) or FHR-3 and RETC-2-ximab (anti-FHR-3, light grey). (A) C3 mRNA expression was reduced by 27%, (B) CFB mRNA expression was reduced by 48%, and (C) C3AR mRNA expression was reduced by 21% when incubated with FHR-3 and RETC-2-ximab compared to FHR-3 alone. Shown is the relative mRNA expression to FHR-3 treated cells in %. Mean with standard deviation is shown. *p < 0.05. Unpaired t-test (n = 2).