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Effects of multiple doses of BG (160 mg/kg, i.g.) for consecutive 7 days on MDZ hydroxylation activity in rat liver microsomes (n = 6).
| Parameter | Female | Male | ||
|---|---|---|---|---|
| Control | BG | Control | BG | |
| Vmax (μmol/min/mgprotein) | 164.70 ± 33.08 | 215.07 ± 4.87 | 899.73 ± 94.13* | 1,026.20 ± 111.98 |
| Km (μM) | 1.26 ± 0.23 | 2.10 ± 0.57 | 7.31 ± 1.53* | 8.75 ± 2.38 |
| CLin (μl/min/mg protein) | 132.14 ± 26.53 | 119.47 ± 36.91 | 125.97 ± 24.50 | 122.50 ± 31.15 |
Values are means ± SD.
*p < 0.05, compared with the female group.
