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. 2021 Nov 8;12:761763. doi: 10.3389/fphar.2021.761763

TABLE 4.

Effects of multiple doses of BG (160 mg/kg, i.g.) for consecutive 7 days on sorafenib N-oxide activity in rat liver microsomes (n = 6).

Parameter	Female		Male
Parameter	Control	BG	Control	BG
V_max (nmol/min/mgprotein)	1,405.2 ± 782.3	1,714.13 ± 749.52	12,705.3.2 ± 2,379.8*	16,176.5 ± 976.51
K_m (μM)	17.42 ± 5.44	14.24 ± 6.36	37.87 ± 8.30*	31.46 ± 23.01
CL_in (μl/min/mg protein)	76.73 ± 20.63	121.23 ± 26.90	344.0 ± 89.16*	686.44 ± 471.01

Rat values are means ± SD.

*p < 0.05, compared with the female group.