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. 2021 Nov 8;12:731994. doi: 10.3389/fendo.2021.731994

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Copyright © 2021 Høgsted, Borgsted, Dam, Nasser, Rye Jørgensen, Ozenne, Stenbæk and Frokjaer

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview on study population selection from the CIMBI database. Participants recruited from the Center for Integrated Molecular Brain Imaging (CIMBI) database. Inclusion criteria were healthy women with no psychiatric history in the reproductive age <50 years. A complete dataset was required with concurrent information on cortisol awakening response (CAR), Letter-Number-Sequence (LNS) test, and contraceptive use. Exclusion criteria were (1) women above 45 years of age with early menopause or unknown menopausal status measured with follicle stimulation hormone (FSH), (2) incorrect collection of home cortisol samples, and (3) hormonal contraceptives other than OCs or intrauterine devices (IUDs). Further, six women had incomparable cortisol data due to batch variations of the cortisol saliva samples.