Table 1.
Main characteristics of the studies included. Patients treated with EUS-guided RFA technique. NA: not applicable, F: female, M: male, RFA: radifrequency ablation, p.: patient, EUS: endoscopic ultrasound.
| Study population | Country | No. of patients with insulinoma | Gender (M\F) | Age (y) | Indication for EUS-RFA | No of insulinomas | No of sessions | No of passes | Watts | RFA duration (s) | Glucose (mmol/L) | Insulin (pmol/L) | C-peptid (pmol/L) | Type of adverse event | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| before RFA | after RFA | before RFA | after RFA | before RFA | after RFA | ||||||||||||
| Bas-Cutrina et al. 22 | Spain | 1 | F | 63 | comorbidity | 1 | 1 | 3 | 10 | 360 | NA | NA | NA | NA | NA | NA | no |
| Choi et al. 25 | Korea | 1 | M | 34 | refuse and high surgical risk | 1 | 1 | 3 | 50 | 10 | NA | NA | NA | NA | NA | NA | no |
| De Nucci et al. 28 | Italy | 1 | F | 76 | comorbidity | 1 | 1 | 2 | 10 | 60 | 1.9 | NA | NA | NA | NA | NA | no |
| Godat et al. 30 | Switzerland | 1 | NA | NA | NA | 1 | 1 | 3 | 50 | 10 | NA | NA | NA | NA | NA | NA | abd. pain |
| Jonica and Wagh 31 | USA | 1 | F | 57 | comorbidity | 1 | 1 | 5 | 30 | 20 | 2.22 | 7.66 | 257 | NA | NA | NA | no |
| Kandula et al. 32 | India | 1 | F | 41 | refuse surgery | 2 | NA | NA | NA | NA | 2.22 | NA | NA | NA | NA | NA | abd. pain, acute pancreatitis |
| Kluz et al. 34 | Poland | 1 | M | 40 | refuse surgery | 1 | 3 | NA | 50 | 10 | NA | NA | NA | NA | NA | NA | acute necro. pancreatitis |
| Oleinikov et al. 40 | Israel | 7 | M | 44 | refuse surgery | 1 | 1 | NA | 10-50 | 5-12 | 3.38 ± 0.34 | 6.61 ± 0.13 | NA | NA | NA | NA | no |
| M | 65 | 1 | 1 | 50 | 5-12 | ||||||||||||
| M | 61 | 1 | 1 | 10-50 | 5-12 | ||||||||||||
| M | 73 | 1 | 1 | 10-50 | 5-12 | ||||||||||||
| F | 28 | 1 | 1 | 10-50 | 5-12 | ||||||||||||
| F | 56 | 1 | 1 | 10-50 | 5-12 | ||||||||||||
| F | 37 | 1 | 1 | 10-50 | 5-12 | ||||||||||||
| Sharma et al. 44 | USA | 2 | M | 44 | refuse surgery | 1 | 3 | NA | 10 | NA | 1.72 | NA | NA | NA | NA | NA | NA |
| F | 37 | 1 | 3 | 10 | NA | ||||||||||||
| Waung et al. 50 | UK | 1 | F | 70 | comorbidity | 1 | 3 | 3 | 10 | NA | 1.6 | NA | 120 | NA | 2418 | NA | NA |
| Lakhtakia et al. 53 | India | 10 | NA | NA | NA | 13 | 8 p./1 2 p./>1 |
NA | NA | NA | NA | normal | NA | normal | NA | normal | Abd.pain, acute panc. |