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. 2021 Nov 19;9(11):e003065. doi: 10.1136/jitc-2021-003065

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Depiction of CAR and coreceptor constructs utilizing the TLR signaling pathway. (A) Third-generation, CD19-targeting, 1928T2z CAR construct incorporating the intracellular TIR signaling domain derived from TLR2, alongside the intracellular signaling domain of CD28 and CD3ζ. (B) Third-generation, CD19-targeting, CAR.MC.ζ construct incorporating a truncated version of MyD88 lacking its TIR domain and the intracellular signaling portion of CD40 alongside CD3ζ. (C) CD8α:MyD88, a synthetic coreceptor that fuses together the extracellular and transmembrane domains of CD8α and the intermediate and death domains of MyD88. CAR, chimeric antigen receptor; MyD88, myeloid differentiation primary response 88; TIR, toll/interleukin-1 receptor; TLR, Toll-like receptor.