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Inhibition of Dkk and Bmp4 gene expression by treatment with an inhibitor on FGF signaling. Gene expression pattern of Bmp4 and Dkk in the anterior margin of the limb at developing stage 24HH. (A) Dkk expression inhibition was observed after 2 h of treatment with SU5402, while Bmp4 was inhibited after 4 h. The gene expression pattern of Dkk and Bmp4 was not modified at least 4 h after (B) FGF8- and (C) FGF10-treatment.
