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. 2021 Nov 8;9:703836. doi: 10.3389/fcell.2021.703836

FIGURE 5.

FIGURE 5

BMP signaling regulates Fgf8, Bmp4, Dkk, Msx2, and Bambi gene expression. Regulation of (A–C) Fgf8, (D–F) Bmp4, (G–I) Dkk, (J–L) Msx2, (M–O) Bambi gene expression in the anterior limb margin after BMP4, BMP7, or Noggin. Fgf8 (B, C) and Bmp4 (D, E) are downregulated after 4 h of BMP4 or BMP7. Notice the stronger effect of BMP4 than BMP7. In contrast, NOGGIN-treatment maintained the expression of both genes after treatments. (G–I) Upregulation of Dkk gene expression after 4 h of BMP4- or BMP7-treatment and downregulation of Dkk after 4 h of NOGGIN treatment. (J–L) Msx2 and (M–O) Bambi gene expression were upregulated by BMP4 and BMP7. In contrast, NOGGIN inhibited Bambi expression during the first 4 h of treatment but not Msx2 [Panel (L, O)].