TABLE 2.

Literature review of patients with rare, acquired tremor syndromes who underwent DBS of the DRT/DRTT.

Authors	n	Diagnoses	mean FU (mo.)	DBS target	DRT/DRTT targeting method	Outcome data
Bargiotas et al., 2021	4	HT (post-stroke)	48	Unilateral Vim (2) or DRTT (2)	direct	Average FTMTRS reduction at last FU*: Vim 29.25%; DRTT 15.30%
Morishita et al., 2019	7	ET (3), PD (2), HT [post-head trauma (1), post-stroke (1)]	11.1 ± 6.4	Bilateral thalamic (red nucleus & Vim) intended to engage the DRT	direct	Reductions in tremor rating scale scores for ET, PD, and HT patients were 42.63, 71.43, and 56.09%, respectively
Coenen et al., 2011	1	Myoclonic head tremor	3	Bilateral DRT	direct	ETRS score improved by 18% postoperatively; >90% control of head tremor at 3 months
Plaha et al., 2008	18	PD (5), HT (1), cerebellar tremor (1), ET (6), MS tremor (4), dystonic tremor (1)	12	Bilateral cZI (intended to engage white matter tracts surrounding the subthalamic region)	indirect	Tremor improvement for all diagnoses: PD resting 94.8%, postural 88.2%; ET 75.9%; HT 70.2%; cerebellar tremor 60.4%; MS tremor 57.2%; dystonic tremor improved both tremor and dystonia
Kudo et al., 2001	1	HT (post-stroke)	N/A	Bilateral Vim (engaging the DRTT)	indirect	almost complete abolition of tremor in both the head and arm, though some ataxia of arm still present

Few case reports and series describing intentional targeting of dentato-rubro-thalamic circuit implicated white matter fiber tracts. Multiple targeting and tremor evaluation strategies are reported.

*3 of 4 patients saw sustained improvement for 3 years, followed by deterioration of ADL performance to worse than baseline by 4 years; 1 of 4 patients saw sustained improvement for 9 years. FU – follow-up; HT – Holmes’ tremor; ET – essential tremor; PD – Parkinson’s disease; MS – multiple sclerosis; DRT/DRTT – dentato-rubro-thalamic tract; cZI – caudal zona incerta; FTMTRS – Fahn-Tolosa-Marin Tremor Rating Scale; ETRS – Essential Tremor Rating Scale.