Table 3.
Quantitative Uptake and Drug Concentration Available in Conditioned Media of Free CPT, Lf-CPT, Free ETP, and Lf-ETP on Rb Y79 CSCs and Non-CSCs
| Characteristic | Drug Uptake (µg/106 Cells), Mean (SD) | Drug Concentration in CM After 48 Hours (µg/106 Cells), Mean (SD) | Drug Retention (%) Into the Cells After 48 Hours |
|---|---|---|---|
| Free CPT-Rb Y79 CSCs | 9.99 (0.7) | 8.37 (1.34) | 15.46 |
| Lf-CPT-Rb Y79 CSCs | 17.38 (1.84) | 7.92 (1.47) | 54.43 |
| Free CPT-Rb Y79 non-CSCs | 8.09 (1.29) | 2.97 (1.32) | 63.28 |
| Lf-CPT-Rb Y79 non-CSCs | 16.1 (1.2) | 3.31 (1.01) | 79.44 |
| Free ETP-Rb Y79 CSCs | 13.9 (3.57) | 13.59 (0.77) | 2.23 |
| Lf-ETP-Rb Y79 CSCs | 28.07 (4.56) | 10.11 (1.7) | 63.98 |
| Free ETP-Rb Y79 non-CSCs | 13.61 (3.64) | 5.55 (1.33) | 59.40 |
| Lf-ETP-Rb Y79 non-CSCs | 23.87 (3.67) | 4.07 (1.35) | 82.94 |