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. 2021 Nov 16;62(14):14. doi: 10.1167/iovs.62.14.14

Figure 6.

Figure 6.

Absence of CXCL2 and CXCL10 resulted in reduced intraocular inflammation during experimental Bacillus endophthalmitis. MPO concentrations were significantly reduced in the absence of CXCL2 and CXCL10. C57BL/6J (C57), CXCL2−/−, and CXCL10−/− mouse eyes were injected with 100 CFU B. cereus. At 8, 10, 12, 14, and 16 hours postinfection, infected eyes were harvested and infiltration of PMN was assessed by quantifying MPO in whole eyes by sandwich ELISA. At 8, 10, and 12 hours postinfection, MPO levels were significantly reduced (P ≤ 0.05) in CXCL2−/− and CXCL10−/− eyes compared to that of C57 eyes. At 14 and 16 hours postinfection, MPO levels were significantly reduced in CXCL2−/− eyes compared to that of C57 eyes. No difference in MPO levels between CXCL10 and C57 were found at these time points. Compared to CXCL10−/−, CXCL2−/− eyes had reduced levels of MPO at 12 and 14 hours postinfection. Values represent means ± SEM for n ≥ 5 eyes per group per time point with at least 3 independent experiments. *P ≤ 0.05, **P ≤ 0.01, and nsP ≥ 0.05.