Figure 9.

Summary of critical findings. Experimental B. cereus endophthalmitis was induced in WT, CXCL2^−/−, and CXCL10^−/− mice. After various times postinfection, infected eyes were analyzed for pathogenesis. Absence of either CXCL2 or CXCL10 did not affect the intraocular Bacillus growth. Compared to WT, CXCL2^−/− and CXCL10^−/− mice had significantly retained retinal function, reduced PMN infiltration, and mild to moderate retinal damage. B. cereus-infected WT mouse eyes were treated with anti-CXCL2 or anti-CXCL10 antibodies with or without gatifloxacin at 2 hours postinfection. Compared to untreated eyes, treated eyes showed significantly retained retinal function, reduced PMN infiltration, and mild retinal damage. Created with BioRender.com.