TABLE 5.
Colon RNA transcriptional differences in male UC Davis Type 2 Diabetes Mellitus (UCD‐T2DM) rats 3 months post diabetes compared to nondiabetic rats 1
| Symbol | Entrez | Log fold change | Log CPM | F | FDR | Description |
|---|---|---|---|---|---|---|
| Adamts12 | 294809 | −1.32 | 1.177 | 22.526 | 0.139 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 [Source: RGD Symbol; Acc:1307323] |
| Igfbp3 | 24484 | −1.19 | 6.711 | 25.951 | 0.139 | Insulin‐like growth factor binding protein 3 [Source: RGD Symbol; Acc:2874] |
| Gata2 | 25159 | −1.06 | 2.582 | 22.361 | 0.139 | GATA binding protein 2 [Source:RGD Symbol; Acc:2664] |
| Pzp | 252922 | −1.02 | 5.586 | 26.349 | 0.139 | pregnancy‐zone protein [Source:RGD SYMBOL; Acc:628643] |
| Col1a1 | 29393 | −1.00 | 7.688 | 48.912 | 0.033 | Collagen type I alpha 1 chain [Source: RGD Symbol; Acc:61817] |
| Col6a4 | 315981 | −1.00 | 4.827 | 29.866 | 0.139 | collagen, type VI, alpha 4 [Source:RGD Symbol; Acc:1564060] |
| Col3a1 | 84032 | −0.96 | 8.820 | 43.165 | 0.035 | Collagen type III alpha 1 chain [Source: RGD Symbol; Acc:71029] |
| Aif1l | 362107 | −0.95 | 2.570 | 23.604 | 0.139 | Allograft inflammatory factor 1‐like [Source: RGD Symbol; Acc:1305081] |
| Igsf10 | 310448 | −0.92 | 3.329 | 21.061 | 0.158 | Immunoglobulin superfamily, member 10 [Source: RGD Symbol; Acc:735030] |
| C1qtnf2 | 497886 | −0.90 | 3.452 | 22.427 | 0.139 | C1q and tumor necrosis factor‐related protein 2 [Source: RGD Symbol; Acc:1561041] |
| Sparc | 24791 | −0.81 | 8.298 | 19.955 | 0.195 | Secreted protein acidic and cysteine rich [Source: RGD Symbol; Acc:3742] |
| Cxcl12 | 24772 | −0.74 | 4.566 | 23.507 | 0.139 | C‐X‐C motif chemokine ligand 12 [Source: RGD Symbol; Acc:3651] |
| Stmn1 | 29332 | −0.50 | 5.852 | 20.940 | 0.158 | Stathmin 1 [Source: RGD Symbol; Acc:2992] |
| Fgfr4 | 25114 | −0.47 | 5.103 | 23.257 | 0.139 | fibroblast growth factor receptor 4 [Source: RGD Symbol; Acc:2612] |
| Fut2 | 58924 | 0.367 | 8.273 | 22.921 | 0.139 | Fucosyltransferase 2 [Source: RGD Symbol; Acc:2639] |
| Med21 | 312849 | 0.402 | 5.584 | 24.831 | 0.139 | Mediator complex subunit 21 [Source: RGD Symbol; Acc:1309836] |
| Aldh2 | 29539 | 0.463 | 9.486 | 24.040 | 0.139 | Aldehyde dehydrogenase 2 family (mitochondrial) [Source: RGD Symbol; Acc:69219] |
| Kcne3 | 63883 | 0.495 | 7.682 | 26.004 | 0.139 | Potassium voltage‐gated channel subfamily E regulatory subunit 3 [Source: RGD Symbol; Acc:621384] |
| Abcc5 | 116721 | 0.575 | 6.186 | 22.060 | 0.141 | ATP binding cassette subfamily C member 5 [Source: RGD Symbol; Acc:70913] |
| Gcg | 24952 | 0.706 | 7.336 | 25.171 | 0.139 | Glucagon [Source: RGD Symbol; Acc:2668] |
| Eva1c | 360695 | 0.781 | 4.148 | 27.933 | 0.139 | Eva‐1 homolog C [Source: RGD Symbol; Acc:1307569] |
| Pde9a | 191569 | 0.808 | 7.642 | 24.820 | 0.139 | Phosphodiesterase 9A [Source: RGD Symbol; Acc:621035] |
| Susd4 | 289335 | 0.829 | 2.220 | 21.239 | 0.158 | Sushi domain containing 4 [Source: RGD Symbol; Acc:1564043] |
| Slc6a9 | 116509 | 0.899 | 4.407 | 23.544 | 0.139 | Solute carrier family 6 member 9 [Source: RGD Symbol; Acc:621243] |
Abbreviation: CPM, counts per million.
1
Comparison between UCD‐T2DM nondiabetic rats (ND, n = 6) and UCD‐T2DM rats 3‐months post‐onset of diabetes (D3M, n = 6). Analysis conducted using the edgeR pipeline. Log fold change represents the ratio of D3M to ND groups.