TABLE 6.
Pathway analysis of transcripts differing between D3M rats and both ND and D1M rats 1
| Category | Term | Count % | Symbols | List total | Pop hits | Pop total | Fold enrichment | FDR |
|---|---|---|---|---|---|---|---|---|
| rno04974: Protein digestion and absorption | 9 | 2.8 | Slc6a19, Slc3a2, Atp1a1, Dpp4, Atp1b1, Slc7a7, Slc15a1, Ace2, Xpnpep2 | 137 | 89 | 7749 | 5.72 | 0.0293 |
| rno04973: Carbohydrate digestion and absorption | 6 | 1.9 | Slc2a2, Atp1a1, Slc2a5, Slc37a4, Atp1b1, Slc5a1 | 137 | 41 | 7749 | 8.28 | 0.0652 |
| rno04144: Endocytosis | 13 | 4.1 | Igf2r, Snx32, Ehd1, Chmp4c, Washc2c, Prkcz, Mdm2, Asap1, Arfgap3, Dnm2, Smap1, Arpc2, Epn2 | 137 | 270 | 7749 | 2.72 | 0.1695 |
| rno04978: Mineral absorption | 5 | 1.6 | Slc6a19, Trpm6, Atp1a1, Atp1b1, Slc5a1 | 137 | 39 | 7749 | 7.25 | 0.2169 |
| rno04976: Bile secretion | 6 | 1.9 | Atp1a1, Abcg2, Slc51b, Slc51a, Atp1b1, Slc5a1 | 137 | 71 | 7749 | 4.78 | 0.2983 |
| rno04931: Insulin resistance | 7 | 2.2 | Slc2a2, Slc27a4, Trib3, Prkag2, Ptprf, Prkcz, Irs2 | 137 | 110 | 7749 | 3.60 | 0.3940 |
| rno01100: Metabolic pathways | 32 | 10 | Fut1, Anpep, Dgat2, Ampd3, Papss2, Acsl5, B3galnt1, Polr3c, Dhrs9, Lpin3, Ahcyl2, Etnk1, Aldob, Khk, Dlst, Rdh16, Acat1, Bckdhb, Plcd1, Chpf, Pmm2, Fahd1, St6galnac1, Cyp3a9, Coq5, Gpat3, Chdh, Btd, B4galt6, Hsd17b4, Hsd17b2, Pla2g12b | 137 | 1285 | 7749 | 1.41 | 0.8438 |
Abbreviation: FDR, false discovery rate.
1
UC Davis Type 2 Diabetes Mellitus rats were non‐diabetic (ND, n = 6), had recent diabetes (2‐week post‐onset of diabetes; D1M, n = 6), or 3‐month post‐onset of diabetes (D3M, n = 6). Transcript expression determined by RNAseq analysis. Differential abundance between rat groups was assessed using edgeR pipeline. Pathway analysis conducted by the DAVID Bioinformatics Resource 6.8. Only pathways with p < 0.05 are provided.