FIGURE 4.

4 S22A‐LMNA phosphorylation mutant alters steady‐state inactivation. Voltage‐dependency of the steady‐state inactivation and activation of cells co‐transfected with SCN5A + WT‐LMNA (black) versus SCN5A + S22A‐LMNA (red, a) or S22D‐R545H‐LMNA (red, b). Inactivation: SCN5A + WT‐LMNA versus SCN5A + S22A‐LMNA p < 0.05. No significant differences in other inactivation or activation curves. Insets show pre‐pulse inactivation (left) and step‐pulse activation (right) protocols. Data are mean ± SE