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. 2021 Nov 16;2(11):100446. doi: 10.1016/j.xcrm.2021.100446

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© 2021.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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ANGPTL3 vaccine durability as assessed in C57BL/6J mice

(A) Circulating antibody titers of mice at 6, 20, and 30 weeks after the first E3 immunization. Values are reported as the serum dilution giving half-maximal binding (optical density: OD50%). p < 0.01 for interaction between week and E3 treatment (n = 11 per group).

(B) Non-fasting TG levels in circulation of mice before immunization and at 6, 20, and 30 weeks after the first E3 immunization. p < 0.01 for interaction between week and E3 treatment (n = 11 per group).

(C) Body weight of mice before immunization and at 6, 20, and 30 weeks after the first E3 immunization (n = 11 per group). p = 0.88 for interaction between week and E3 treatment. Results are expressed as mean ± SEM n.s., not significant. ∗p < 0.05 versus KLH (control) group. ^†p < 0.01 versus KLH (control) group.