Reagent or resource	Source	Identifier
Antibody
anti-Bovine Serum Albumin (BSA) antibody	Abcam	Cat# ab79827, RRID:AB_1603068
Sheep anti-Mouse IgG - Horseradish Peroxidase antibody	GE Healthcare	Cat# NA931, RRID:AB_772210
Chemicals, peptides, and recombinant proteins
Angiopoietin-like 3 (ANGPTL3) peptide	Peptide Institute	N/A
BSA conjugated to ANGPTL3 peptide	Peptide Institute	N/A
keyhole limpet hemocyanin (KLH)conjugated to ANGPTL3 peptide	Peptide Institute	N/A
KLH	G-BIOSIENCES	Cat# 786-088 CAS No.9013-72-3
Freund’s Complete Adjuvant	FUJIFILM Wako Pure Chemical Corporation	Cat# 014-09541
Freund’s Incomplete Adjuvant	FUJIFILM Wako Pure Chemical Corporation	Cat# 011-09551
Recombinant Mouse ANGPTL3 Protein	R&D Systems	Cat# 136-AN
RPMI-1640	FUJIFILM Wako Pure Chemical Corporation	Cat# 189-02025
Fetal Bovine Serum (FBS)	Sigma-Aldrich	Cat# 172012
Penicillin-Streptomycin solution	FUJIFILM Wako Pure Chemical Corporation	Cat# 168-23191
2-mercaptoethanol	FUJIFILM Wako Pure Chemical Corporation	Cat# 135-14352; CAS No.60-24-2
Phytohemagglutinin	FUJIFILM Wako Pure Chemical Corporation	Cat# 161-15251; CAS No.9008-97-3
Critical commercial assays
Mouse ANGPTL3 Assay Kit	Immuno-Biological Laboratories	Cat# 27410
Mouse ANGPTL8 Assay Kit	MyBioSource, Inc	Cat# MBS456830
LabAssay Triglyceride	FUJIFILM Wako Pure Chemical Corporation	Cat# 290-63701
LabAssay NEFA	FUJIFILM Wako Pure Chemical Corporation	Cat# 290-63601
Lipid Extraction Kit	Cell Biolabs, Inc.	Cat# STA-612
Lipid Quantification Kit (Fluorometric)	Cell Biolabs, Inc.	Cat# STA-617
PrimeScript RT reagent Kit	Takara Bio Inc.	Cat# RR037B
SYBER Premix Ex TaqII	Takara Bio Inc.	Cat# RR041A
Cell Counting Kit-8	DOJINDO	Cat# CK04
Mouse IFN-γ Quantikine ELISA Kit	R&D Systems	Cat# MIF00
Mouse IL-2 Quantikine ELISA Kit	R&D Systems	Cat# M2000B
Mouse IL-4 Quantikine ELISA Kit	R&D Systems	Cat# M4000B
Mouse IL-10 Quantikine ELISA Kit	R&D Systems	Cat# M1000B
Experimental models: Organisms/strains
Mouse: B6.Cg-Lepob/J	Charles River Laboratories	RRID:IMSR_JAX:000632
Mouse: B6.KOR/StmSlc-Apoeshl	Japan SLC	MGI Cat# 3716940; RRID:MGI:3716940
Mouse: C57BL/6J	Charles River Laboratories	RRID:IMSR_JAX:000664
Software and algorithms
GraphPad Prism (version 8.4.3)	GraphPad Software Inc.	RRID:SCR_002798
Photoshop 2021 (version 22.5)	Adobe Inc.	RRID:SCR_014199
STATA MP (version 15.0)	StataCorp.	RRID:SCR_012763
Oligonucleotides
Primers for realtime PCR	This paper	Table S2