Table 2.
Quartile Group Distribution of TMB According to Clinicopathological Characteristics
| Characteristic | Total (N) | TMB (%) | ||||
|---|---|---|---|---|---|---|
| Group 1 (0.00-0.625) (n=19) |
Group 2 (0.626-1.25) (n=12) |
Group 3 (1.251-2.50) (n=14) |
Group 4 >2.50 (n=13) |
p value | ||
| ER | ||||||
| Negative | 20 | 3 (15.8) | 1 (8.3) | 8 (57.1) | 8 (61.5) | 0.003* |
| Positive | 38 | 16 (84.2) | 11 (91.7) | 6 (42.9) | 5 (38.5) | |
| PR | ||||||
| Negative | 26 | 4 (21.1) | 4 (33.3) | 9 (64.3) | 9 (69.2) | 0.017* |
| Positive | 32 | 15 (78.9) | 18 (66.7) | 5 (35.7) | 4 (30.8) | |
| HER2 | ||||||
| Negative | 41 | 15 (78.9) | 10 (83.3) | 7 (50.0) | 9 (69.2) | 0.22 |
| Positive | 17 | 4 (21.1) | 2 (16.7) | 7 (50.0) | 4 (30.8) | |
| Triple negative | ||||||
| Non-TN | 49 | 18 (94.7) | 12 (100.0) | 11 (78.6) | 8 (61.5) | 0.025* |
| TN | 9 | 1 (5.3) | 0 (0.0) | 3 (21.4) | 5 (38.5) | |
| Ki67 | ||||||
| <14% | 25 | 14 (73.7) | 6 (50.0) | 4 (28.6) | 1 (7.7) | 0.0015* |
| ≥14% | 33 | 5 (26.3) | 6 (50.0) | 10 (71.4) | 12 (92.3) | |
| Grade | ||||||
| 1 | 4 | 0 (0.0) | 2 (16.7) | 0 (0.0) | 2 (15.4) | |
| 2 | 45 | 17 (89.5) | 6 (50.0) | 12 (85.7) | 10 (76.9) | 0.12 |
| 3 | 9 | 2 (10.5) | 4 (33.3) | 2 (14.3) | 1 (7.7) | |
| LN | ||||||
| 0 | 10 | 4 (21.1) | 2 (16.7) | 3 (21.4) | 1 (7.7) | |
| 1 to 3 | 17 | 4 (21.1) | 3 (25.0) | 3 (21.4) | 7 (53.8) | 0.52 |
| >3 | 31 | 11 (57.9) | 7 (58.3) | 8 (57.2) | 5 (38.5) | |
| Menopausal status | ||||||
| Premenopausal | 17 | 6 (31.5) | 5 (41.7) | 3 (21.4) | 3 (23.1) | 0.66 |
| Postmenopausal | 41 | 13 (68.5) | 7 (58.3) | 11 (78.6) | 10 (76.9) | |
| Age | ||||||
| <55 | 27 | 9 (47.4) | 7 (58.3) | 6 (42.9_ | 5 (38.5) | 0.78 |
| ≥55 | 31 | 10 (52.6) | 5 (41.7) | 8 (57.1) | 8 (61.5) | |