Table 1.
Demographic Data and Clinical Characteristics of the Study Subjects at the Beginning of Antiretroviral Therapy (n=6637)
| Variables | Thrombocytopenia (n=176) | Thrombocytosis (n=388) | Normal (n=6073) |
|---|---|---|---|
| Age (years) | 34(29, 46) | 30(25, 38) | 30(26, 37) |
| Sex | |||
| Male | 166 (94.3) | 364(93.8) | 5820(95.8) |
| Female | 10 (5.7) | 24(6.2) | 253(4.2) |
| Transmission route | |||
| Homosexual | 115 (65.3) | 294(75.8) | 4893(80.6) |
| Heterosexual | 38 (21.6) | 58(14.9) | 733(12.1) |
| Other/unknown | 23 (13.1) | 36(9.3) | 447(7.3) |
| WHO clinical stage | |||
| I–II | 152(86.4) | 347(91.1) | 5513(92.2) |
| III–IV | 24 (13.6) | 34(8.9) | 469(7.8) |
| BMI (kg/m2) | |||
| 18.5–24.0 | 88 (66.2) | 186(61.4) | 3136(65.6) |
| < 18.5 | 19 (14.3) | 40(13.2) | 472(9.9) |
| >24.0 | 26 (19.5) | 77(25.4) | 1171(24.5) |
| HBsAg | |||
| Negative | 148(85.5) | 363(95.3) | 5649(94.7) |
| Positive | 25(14.5) | 18(4.7) | 314(5.3) |
| Anti-HCV | |||
| Negative | 166(96.0) | 378(99.5) | 5833(98.0) |
| Positive | 7(4.0) | 2(0.5) | 119(2.0) |
| Syphilis | |||
| Negative | 105(64.4) | 205(59.8) | 3688(64.9) |
| Positive | 58(35.6) | 138(40.2) | 1992(35.1) |
| Baseline VL (copies/mL) | |||
| <100,000 | 88(51.5) | 237(62.7) | 4143(70.4) |
| ≥100,000 | 83(48.5) | 141(37.3) | 1740(29.6) |
| Baseline CD4 count (cells/μL) | |||
| <350 | 144(82.8) | 219(56.9) | 3595(60.0) |
| ≥350 | 30(17.2) | 166(43.1) | 2397(40.0) |
| Baseline CD4/CD8 ratio | |||
| <0.4 | 151(87.3) | 272(71.0) | 4238(71.9) |
| ≥0.4 | 22(12.7) | 111(29.0) | 1658(28.1) |
| WBC (×109 /L) | |||
| ≥4.0 | 106(60.2) | 353(91.0) | 5288(87.1) |
| <4.0 | 70(39.8) | 35(9.0) | 785(12.9) |
| HGB (g/L) | |||
| ≥110(Female) or ≥120(Male) | 119(67.6) | 308(79.4) | 5651(93.1) |
| <110(Female) or >120(Male) | 57(32.4) | 80(20.6) | 422(6.9) |
| NLR | |||
| <2.0 | 79(46.5) | 168(45.8) | 3589(61.2) |
| 2.0–4.0 | 60(35.3) | 130(35.4) | 1791(30.5) |
| >4.0 | 31(18.2) | 69(18.8) | 488(8.3) |
Notes: Data are presented as n (%), or median (interquartile range). Variable had missing values: WHO clinical stage = 98; BMI = 1422; HBV = 120; HCV =132; Syphilis = 451; VL = 205; CD4 count = 86; CD4/CD8 ratio = 185; NLR = 232.
Abbreviations: WHO, world health organization; BMI, body mass index; HBsAg, hepatitis B surface antigen; Anti-HCV, antibody to hepatitis C virus; VL, viral load; WBC, white blood cell; HGB, haemoglobin; NLR, neutrophil-lymphocyte ratio.